New York, USA – May 28, 2021 – Creative Biostructure, a biotechnology company specialized in structural biology that offers dedicated services aimed to determine the structure of biomolecules, such as proteins, nucleic acids, and their complex, now offers all-in-one X-ray crystallography pipeline that covers all technical stages from gene synthesis to structure determination.
X-ray crystallography is currently the most favored method in the determination of protein and other macromolecular structures. A necessary condition for successful X-ray crystallographic applications is to obtain single crystals of the protein of interest. Data were then collected by diffraction of X-rays from ordered patterned single crystals with atomic orientation. The assembly of atoms and molecules in the crystal can be deduced from measurements of X-ray scattering.
At present, 120,000 protein structures solved by X-ray crystallography experiments have been stored in the Protein Data Bank, accounting for about 90% of the solved proteins, suggesting that X-ray crystallography dominates the structure determination.
Now, integrated gene to structure services at Creative Bio structure mainly include: Construct design and expression optimization, Crystallization-grade protein purification, Protein initial crystallization screening, Optimization of crystallization conditions, X-ray screening and dataset collection, and Data analysis and structure determination.
Moreover, Creative Biostructure provides various crystallization strategies, particularly for membrane protein crystallization. Services include: Co-crystallization, Bicelle-Protein Crystallization, Lipidic Cubic Phase (LCP) Crystallization, Controlled In Meso Phase (CIMP) Crystallization, Trace Fluorescent Labeling Crystallization, Crystallization Chaperone Strategies, and Crystallization with Mutant Library Approaches.
“Our services come with well-defined methodologies and instruments yet offer a great deal of flexibility upon your requirements. We can prepare crystallization-grade proteins from scratch or obtain them from you. Supported by advanced structural biology platforms covering mainstream technologies, team of structural biologists and efficient and economical strategies tailored to your requirements, we are sure to help with your structural projects.” Commented Joanna, the chief marketing staff at Creative Biostructure.
NMR spectroscopy, electron microscopy and membrane protein screening are also available at Creative Biostructure to facilitate its customers’ research in structural biology. More information can be viewed here: https://www.creative-biostructure.com/protein-crystallization_26.htm.
About Creative Biostructure
Creative Biostructure is specialized in providing contract services to both academia and biotech/pharmaceutical industries in the field of structural biology. The company offers insightful strategies and cost-effective services on structure determination of macromolecules using X-ray Crystallography, EM, NMR, etc.