New York, USA – November 15, 2021 – Creative Biogene, the world’s leading biotechnology company, focuses on developing high quality products and services, as well as proprietary technology to support the research in the field of life science research, biomedical development and preclinical drug discovery etc. Supporting with gene synthesis and editing platform, Creative Biogene is skilled in covering the needs of early drug discovery and drug development. Recently, Creative Biogene announced the release of its comprehensive shRNA products in order to accelerate RNAi research.
As one of the world’s leading biotechnology companies, Creative Biogene has extensive experience and expertise to provide high-quality RNAi products, including siRNA libraries and shRNA clones, aiming to provide effective, reliable and convenient tools to accelerate RNAi research. Creative Biogene provides a series of shRNAs, which can make tight hairpins for silencing the expression of target genes through RNAi.
The comprehensive shRNA product currently contains approximately 200,000 pre-cloned shRNA constructs. Each gene is represented by multiple vector constructs targeting different regions of the gene sequence. Each shRNA is cloned into a plasmid or lentiviral vector, and each construct is sequence verified to ensure that it matches the target gene.
RNA interference (RNAi) is a conservative biological response to the existence of double-stranded RNA. It mediates resistance to endogenous parasites and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. Because of its characteristics, researchers have used RNAi as a tool to selectively study gene functions, and with the emergence of genome-wide or genomic small interfering RNA (siRNA) libraries for different organisms, its application can be used in real systematic approach.
Creative Biogene can provide a series of siRNA libraries, including human genome siRNA library, human kinase siRNA library, human GPCR siRNA library, human ion channel siRNA library, etc., aiming to provide high-quality products to accelerate research on discovering unknown components of biological pathways or therapeutic targets.
Creative Biogene offers a variety of shRNA cloning options to help customers develop the most time-saving and cost-effective strategy for gene silencing experiments. For most customers, Creative Biogene recommends using shRNA in the viral vector backbone for initial testing (ie, transfection with a plasmid and verification in vitro). Once the most suitable shRNA for the experiment is determined, the construct can be packaged to generate AAV shRNA, adenoviral shRNA, or lentiviral shRNA viral particles for efficient gene knockout.
“Creative Biogene can clone the desired shRNA sequence into any shRNA vector. And we are capable to develop customized solutions to satisfy diverse needs.” said Marcia Brady, the marketing director of Creative Biogene, she also added, “Our in-house experts continually work on developing tools and innovative solutions for the bioresearch community.”
About Creative Biogene
Creative Biogene, as a top-of-its-kind company who holds a leading position and is committed to accelerating the development of human science through biotechnology, offering innovative technologies, products, unique tools and services for research discoveries and product development. With more than 10 years of experience and in-house experts, Creative Biogene has become a well-recognized industry leader to support researchers worldwide.