Pharmaceuticals Grade Sodium Bicarbonate Market size is forecast to reach US$226.3 million by 2027 after growing at a CAGR of 3.5% during 2022-2027. Sodium bicarbonate (commonly known as baking soda), NaHCO3, is a common ingredient in effervescent tablets and is often used as an acidosis controller. Sodium bicarbonate, of pharmaceutical grade, is used as a pH buffering agent for electrolyte replenishing, as a systemic alkalizer, and in topical cleansing solutions. The demand for pharma-grade sodium bicarbonate has been sparked by factors such as product innovation in light of demographic changes and the expansion of government health programs. The sodium bicarbonate market is expected to grow in tandem with the rapid rise in demand for over-the-counter (OTC) drugs. However, the sodium carbonate market is being hampered by environmental and health concerns, as well as the emergence of substitutes, which are limiting the market growth.
The pharmaceutical grade sodium bicarbonate was not majorly influenced due to the Covid-19 pandemic scenario. Amidst the pandemic, there was high utilization of sodium bicarbonate in the pharmaceutical industry. There were various research and studies ongoing to understand the incorporation of sodium bicarbonate in coronavirus treatment. For instance, Mansoura University was studying – “The Role of Sodium Bicarbonate as Adjuvant Treatment of Computed Tomography Identified COVID-19 Pneumonia”. Thus, coronavirus did not have any major negative impact on the market growth of the global pharmaceutical grade sodium bicarbonate market. However, there were supply chain disruptions such as raw material delays or non-arrival, disrupted financial flows. As a result, the market remained restrained but production of sodium bicarbonate continued.
Pharmaceuticals Grade Sodium Bicarbonate Market Segment Analysis – By Application
The active pharmaceutical ingredients (API) segment held the largest share in the pharmaceuticals grade sodium bicarbonate market in 2021 and is forecasted to grow at a CAGR of 3.8% during 2022-2027. Sodium bicarbonate is primarily used as an API and an excipient in the pharma grade sodium bicarbonate market to treat hemodialysis, metabolic acidosis, uncontrolled diabetics, extracorporeal blood circulation, cardiac arrest, and other severe primary lactic acidosis. Sodium bicarbonate is increasingly being used as an active pharmaceutical ingredient in the production of effervescent tablets and as an intermediate in the production of a variety of other pharmaceutical drugs. In the pharmaceutical industry, sodium bicarbonate is used as an active pharmaceutical ingredient to improve drug performance. Increased demand for performing drugs in both established and emerging markets, as well as the need for secondary care small molecules – which are essential in prescription drugs issued by specialists such as oncologists – have all fueled the use of sodium bicarbonate-based active pharmaceutical ingredients in the global pharma industry, according to studies.
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Pharmaceuticals Grade Sodium Bicarbonate Market Segment Analysis – By Geography
North America region held the largest share in the pharmaceuticals grade sodium bicarbonate market in 2021 up to 31.2% and is forecasted to grow at a CAGR of 4.5% during 2022-2027. This recent surge can be attributed to the region’s growing medical industry, which is catalyzing advanced pharmaceutical trends by taking up new research activities. As a result of this demand for active pharmaceutical ingredients such as sodium bicarbonate is on an upsurge in the region. New drugs have an enormous positive influence on global health, prosperity, and economic productivity by saving lives, increasing life spans, reducing suffering, preventing surgeries, and shortening hospital stays due to which pharmaceutical research and development activities are escalating. According to the Congressional Budget Office report, in the last two decades, both R&D spending and the introduction of new drugs have increased. The pharmaceutical industry spent US$83 billion on research and development in 2019. In comparison to the previous decade, the number of new drugs approved for sale increased by 60% between 2010 and 2019, reaching a high of 59 new drugs approved in 2018. According to the 2019 PMPRB Annual Report, from 2011 to 2019, the value of total pharmaceutical sales (including non-patented over-the-counter medicines) in Canada has increased by 35.3% to US$29.9 billion, with 86.7% sold to retail drug stores and 13.3% sold to hospitals. The European Federation of Pharmaceutical Industries and Associations (EFPIA), in 2019 North America accounted for 48.7% of world pharmaceutical sales compared with 22.9% for Europe. Thus, it is evident from the above statistics that the pharmaceutical industry is flourishing in the region, which is accelerating the demand for pharmaceuticals grade sodium bicarbonate in North America during the forecast period.
Pharmaceuticals Grade Sodium Bicarbonate Market Drivers
Increasing Research and Development Activities
There are increasing research and development activities to unlatch new applications of pharmaceuticals grade sodium bicarbonate. Giving pharma-grade sodium bicarbonate to women in labor increased their chances of having a natural, vaginal delivery, according to researchers from the University of Liverpool and the Karolinska Institute in Sweden. A group of women was given pharma grade sodium bicarbonate in addition to oxytocin, while another group was given only oxytocin – a drug that helps strengthen contractions. Bicarbonate of soda consumption increased the chances of vaginal delivery by 17 percent when compared to only administering oxytocin, which only helped in a few cases, leaving emergency caesarean section as the only option in the remaining cases. This type of therapeutic use of pharma grade sodium bicarbonate, according to researchers, will reduce Amniotic Fluid Lactate (AFL) levels, which are usually associated with operative interventions. Such kinds of research and developments activities are anticipated to unlatch new applications for pharmaceuticals grade sodium bicarbonate market, thereby driving the market growth.
Flourishing Pharmaceutical Sector
In developing countries with a thriving pharmaceutical sector, low-cost treatments using pharma grade sodium bicarbonate have the potential to improve mortality rates. The global market for pharma-grade sodium bicarbonate therapeutics is expected to benefit from this. According to the European Federation of Pharmaceutical Industries and Associations (EFPIA), during the period 2014-2019 the Brazilian, Chinese and Indian markets grew by 11.2%, 6.9%, and 11.1% respectively compared to average market growth of 5.4% for the top 5 European Union markets and 6.1% for the US market. According to Invest India, The pharmaceutical industry in India is expected to reach US$65 billion by 2024 and US$120 billion by 2030. Due to this increase in the pharmaceutical industry, the pharmaceuticals grade sodium bicarbonate market is expected to exhibit rapid growth over the forecast period. Furthermore, favorable government policies, such as those relating to foreign direct investments, healthcare facilities, and infrastructure development programs like cluster development in the pharmaceuticals sector, are expected to drive revenue growth in the global pharma grade sodium bicarbonate market.
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Pharmaceuticals Grade Sodium Bicarbonate Market Challenges
Availability of Low-Cost Alternatives
Calcium carbonate, calcium chloride, and other sodium bicarbonate substitutes are used in pharmaceutical applications. Limestone, chalk, marble, calcite, seashells, and corals are all examples of calcium carbonate in nature. Sodium bicarbonate is a stronger base than calcium carbonate, even though calcium carbonate is a soluble alkali. The sodium bicarbonate salt is relatively inexpensive, and excessive consumption of sodium source compounds can lead to kidney disease and high blood pressure, which can lead to heart failure or stroke. Calcium carbonate is a better and safer alternative to sodium bicarbonate as a first-line treatment for heartburn. Calcium carbonate is an over-the-counter remedy that works in seconds. Calcium chloride is available in chewable form and has few side effects. Thus, such low-cost alternatives of pharmaceuticals grade sodium bicarbonate are posing a significant challenge for the pharmaceuticals grade sodium bicarbonate market.
Pharmaceuticals Grade Sodium Bicarbonate Industry Outlook
Technology launches, acquisitions, and R&D activities are key strategies adopted by players in the Pharmaceuticals Grade Sodium Bicarbonate market. Pharmaceuticals Grade Sodium Bicarbonate market top companies are:
Novacarb (Novacap Group)
Dr. Paul Lohmann GmbH KG
Natural Soda LLC
Jost Chemical Co.
Tronox Alkali Corporation
EXELA Pharma Sciences, LLC
In September 2019, Exela Pharma Sciences launched Sodium Bicarbonate Injection, USP. Exela’s ANDA for Sodium Bicarbonate Injection was approved in May for four different presentations. The first is an injection of 8.4% sodium bicarbonate in 50mEq/50mL (1mEq/mL) vials. This product has consistently been on the FDA Drug Shortage List, and it is the only FDA-approved Sodium Bicarbonate Injection on the market in the United States.
North America dominates the pharmaceuticals grade sodium bicarbonate market, owing to the increasing demand and research activities for pharmaceuticals grade sodium bicarbonate in the region.
The growing consumption of sodium-based medicines across the globe owing to the high geriatric population is fueling the demand for pharma grade sodium bicarbonate, thereby driving the market growth.
The pharmaceutical grade sodium bicarbonate, when taken as a supplement by young swimmers, was found to increase their performance by regulating the blood buffering power. Such research activities are presenting various opportunities for pharmaceuticals grade sodium bicarbonate.
Sodium Carbonate Market
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