Hepatorenal Syndrome Market is Expected to Grow During the Forecast Period (2019-2032) | Major Companies- Mallinckrodt, BioVie, Cumberland Pharmaceuticals, and Several Others 1
Hepatorenal Syndrome Market is Expected to Grow During the Forecast Period (2019-2032) | Major Companies- Mallinckrodt, BioVie, Cumberland Pharmaceuticals, and Several Others
Hepatorenal Syndrome Market

DelveInsight’s “Hepatorenal Syndrome Market” report provides a thorough comprehension of the Hepatorenal Syndrome historical and forecasted epidemiology, and the Hepatorenal Syndrome market trends in the 7MM [the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom) and Japan]. The Hepatorenal Syndrome market report also proffers an analysis of the Hepatorenal Syndrome treatment algorithm/practice, market drivers, market barriers, and unmet medical needs.


Hepatorenal Syndrome: An Overview

Hepatorenal syndrome (HRS) is characterized as renal dysfunction secondary to a reduction in renal blood flow (RBF) occurring in the setting of underlying cirrhosis and portal hypertension. It is a severe complication of advanced liver disease and characteristically affects patients with cirrhosis and ascites the pathophysiologic hallmark of HRS is severe vasoconstriction of the renal circulation. Pathogenesis of this vasoconstriction involves a complex interaction between increased portal pressure, changes in the systemic arterial circulation, activation of vasoconstrictor factors and suppression of vasodilator factors acting on the renal circulation.


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Some of the key highlights of the Hepatorenal Syndrome Market Report

  • According to the NORD, Hepatorenal syndrome (HRS) is estimated to occur in approximately 8-10 percent of individuals with the accumulation of fluid in the abdomen (ascites) and cirrhosis.
  • A study performed by Salerno et al. in Italy included 253 patients with cirrhosis and renal impairment and the estimated occurrence of HRS was in that study was found to be 45.8% (30% type 1 and 15.8% type 2). Moreover, male preponderance was observed in HRS. It is estimated that 76.3% of type 1 HRS and 70% of type 2 HRS patients were males.
  • The frequency of HRS in fulminant hepatic failure and severe acute alcohol-related hepatitis has been reported to be as high as 55% and 30%, respectively.


Hepatorenal Syndrome Market

Individuals with Hepatorenal Syndrome will have a variety of nonspecific symptoms including fatigue, abdominal pain, malaise, affected individuals may also have symptoms related to advanced liver disease including the ascites, jaundice, splenomegaly, hepatomegaly and others. Hepatorenal Syndrome type I is characterized by a rapid decrease in kidney function and more likely to suffer from hepatic encephalopathy. Hepatorenal syndrome type II causes renal dysfunction that generally progresses much slower than it does in type.


Hepatorenal Syndrome Epidemiology Segmentation

  • Total Incident cases
  • Type-Specific cases
  • Diagnosed and Treatable cases


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Hepatorenal Syndrome Market Outlook

The treatment of Hepatorenal Syndrome (HRS) includes Liver transplantation as the definitive treatment for HRS, but it is not always possible owing to the short survival expectancy. Nevertheless, liver transplantation should still be done in suitable patients even after the improvement of renal function because the outcome of HRS is poor. Therapies introduced during the past few years, such as vasoconstrictor drugs (vasopressin analogs, α-adrenergic agonists) or the transjugular intrahepatic portosystemic shunt (TIPS), are effective in improving renal function.


Hepatorenal Syndrome Companies along with therapies

  • Terlipressin: Mallinckrodt pharmaceuticals
  • Ifetroban: Cumberland Pharmaceuticals, and several others


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Hepatorenal Syndrome Treatment Market

Several treatment options exist, but, at present, only liver transplantation offers genuine hope for cure and longevity. Challenges for the study of HRS include establishing when renal dysfunction in patients with cirrhosis occurs, largely related to the limitations including the uncertain value of renal biomarkers, and the limited availability of pharmacologic and other therapies to address the fundamental underlying pathophysiology.


Hepatorenal Syndrome Market Insights

Although to fulfill the unmet need, much has been learned about the pathophysiology, clinical behavior, and natural history of HRS. Standardized diagnostic criteria have been developed and implemented worldwide, allowing for a more uniform diagnosis and consistent reporting of the disease. One of the most important developments in HRS is the move away from a diagnosis based on a single level of serum Cr to a diagnosis based on dynamic serial changes in serum Cr level such as the recently revised recommendations of the International Ascites Club (IAC) for hepatorenal disorders in cirrhosis. This change has been stimulated by a perceived need to establish more precisely an early diagnosis of the disease.


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Table of content

1. Key Insights

2. Executive Summary

3. Competitive Intelligence Analysis

4. Market Overview at a Glance

5. Disease Background and Overview

6. Patient Journey

7. Hepatorenal Syndrome Epidemiology and Patient Population

8. Treatment Algorithm, Current Treatment, and Medical Practices

9. Hepatorenal Syndrome Unmet Needs

10. Key Endpoints of Hepatorenal Syndrome Treatment

11. Hepatorenal Syndrome Marketed Products

12. Hepatorenal Syndrome Emerging Therapies

13. Hepatorenal Syndrome: Seven Major Market Analysis

14. Attribute analysis

15. 7MM: Market Outlook

16. Access and Reimbursement Overview of Hepatorenal Syndrome

17. KOL Views

18. Market Drivers

19. Market Barriers

20. Appendix

21. DelveInsight Capabilities

22. Disclaimer

23. About DelveInsight

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